Mystery PI3K between cancer cells

PI3K (phosphatidylinositol three kinase) is a cell signaling molecule, the molecule primarily involved in a series of female cancers occur, such as breast cancer, ovarian cancer and endometrial cancer; recently published in the journal Cell One study papers, from Beth - Israel - Deaconess medical Center researchers (Beth Israel Deaconess medical Center) reveals the PI3K new role in the process of glycolysis, glycolysis is a special kind of metabolic processes, which can be facilitated by the generation of biomass energy and cancer cells continue to grow, studies confirm the importance of sugars on cancer cells to survive and provide new information for the development of PI3K inhibitor drugs as a targeted cancer therapy offers hope.

Researcher Dr. Gerburg Wulf representation, PI3K is a cancer cell can be integrated architecture and its main regulators of metabolic processes, and how to coordinate between sugar molecules and broken cell structure is still a puzzle. In normal cells, the external signal activates the cytoskeleton, and the cytoskeleton is not fixed, it is dynamically assembled from the fiber bundle, and continue to flip through, broken ATP molecule to maintain cell shape, the researchers found that when PI3K is activate and intensify ATP broken in a cancer cell occurs, actin fibers and spin-off will release called aldolase enzymes.

PI3K was first discovered 20 years ago, when its function under normal circumstances PI3K pathway would regulate critical cellular functions, including cell growth, motility, proliferation and differentiation, but excessive activation of the PI3K signaling pathway will lead to breast cancer, ovarian cancer and other female cancers occur, based on the above findings, PI3K inhibitor development may be the only way to develop cancer individualized therapy. Researchers believe that suppression of glucose PI3K crushing will have a profound inhibitory effect, which is very important for cancer, because cancer cells depends on the carbohydrate metabolism update from me, it will not only produce energy but also produce Biomass.