MTB mediated hyperthermia or inhibit resistant bacterial infections

With Staphylococcus aureus resistance to antibiotics is growing, scientists urgently need to develop new ways to effectively kill the resistant strains, a recently published in the International Journal of Applied and Environmental Microbiology research papers , researchers from the Chinese Academy of Sciences conducted experiments in rodents, by using a magnetic nanocrystals generate excessive heat (hyperthermia) so as to target kill Staphylococcus aureus.

Specific bacteria, such as MTB MO-1 (Magnetooliva massalia strain MO-1) can be synthesized in the cell magnetic nanocrystals, namely magnetic body (Magnetosomes), when it is placed in a variable magnetic field is generated when the heat; researchers in a particular field can guide the bacteria deep into the affected area to exert a therapeutic effect, of course, the heat generated by the magnetic crystals can not only kill Staphylococcus aureus, which can also kill the bacteria contain nanoparticles, so magnetotactic bacteria (magnetotactic bacteria) or as a "suicide bomb" to effectively kill the resistant bacteria.

For this study, researchers found that MTB can inhibit Staphylococcus aureus infections, and also its interaction with the magnetic field changes the role of raising the temperature to 43 degrees, while the temperature is sufficient to kill the bacteria. More importantly, researchers will increasingly mediated bacterial magnetic hyperthermia applied to the tails of mice infected with Staphylococcus aureus, showed that compared to not accept the terms of the high heat-treated mice, the high heat can accelerate wound Mice heal.

Then researchers MTB cell surface polyclonal antibody was engineered to operate, these antibodies can bind to Staphylococcus aureus MTB can not adsorb other bacteria, when MTB combined with Staphylococcus aureus, magnetic particles tend to produce excessive heat will kill pathogens, and less damage to healthy tissue. Now researchers are investigating the mechanism of action of magnetic trend, they want research to clarify how bacteria interact with the magnetic moment and the magnetic moment of how to transform bacteria formed to guide the movement of biochemical signals.

Finally, the researchers said Song Tao, the magnetic particles are increasingly targeted for treatment of tumors or infected tissues